Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.

نویسندگان

  • J F Manischewitz
  • G V Quinnan
  • H C Lane
  • A E Wittek
چکیده

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 34 2  شماره 

صفحات  -

تاریخ انتشار 1990